Association between chronic hepatitis C virus infection and increased neopterin concentrations in blood donations.

baseline concentrations. The mean 6 SD decrease was 46% 6 14% (range, 25–64%). As shown in Fig. 1, individual values remained within the reference interval over 5 nonconsecutive days. This suggests that information of bone status provided by DPD during antiresorptive therapy is consistent even when the highest CV value reached 15%. In conclusion, we observed—in a short-term study—a lower day-today variation of DPD during antiresorptive therapy than those reported for untreated individuals. This suggests that DPD measurements could provide useful clinical information in the individual patient to appropriate interpretation of bone status and antiresorptive treatment effects. Moreover, these observations point out the need for additional long-term studies to confirm the clinical utility of DPD measurements in patients under antiresorptive therapy.